In Vitro Biopharm Characterization
Membrane permeability can be used to predict drug absorption. Membrane permeabilities and potential uptake/efflux transporters that affect drug absorption can be identified using the Caco-2 and transporter-overexpressed MDCK cell culture models.
The form of a drug in the plasma directly affect therapeutic efficacy. Protein binding and plasma stability of a drug can be determined.
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