Pre- and Formulation Services

Drug Characterization

  • Solubility
  • pKa
  • Log P
  • Stability

Basic Formulation

  • Cosolvent
  • Cyclodextrin
  • Dispersed systems

Advanced Drug Delivery Systems

  • Micro / nanoemulsions
  • Lipsomes
  • Nanoparticles

Pre-clinical Pk/PD Evaluations


  • Method development and validation to quantitate concentrations of drug or metabolite in biological matrix
  • Identification of unknown metabolite using accurate mass

In Vitro Metabolism

  • Drug metabolism characterization using tissue microsomes. S9 fraction, and recombinant enzymes
  • Metabolite profiling & identification

In Vitro Biopharm Characterization

  • Membrane permeability and transporter identification
  • Bindings to plasma proteins, albumin or a- glycoprotein

In Vivo PK

  • PK studies in rats and mice after IV, oral, IP and SC drug administration
  • Dose linearity PK studies
  • Bioavailability studies
  • PK studies on tissue distribution

In Vitro/In Vivo PD Assays

  • Cell proliferation assay
  • Apoptosis assay
  • DNA damage assay
  • Migration/invsion assays
  • Xenograft assay
  • Biomaker assays on tumors from xenograft models
  • Genetic mouse models of PD assays

PK/PD Modeling and Simulation

  • Consultation on experimental design
  • PK modeling development and simulation
  • PD modeling and determination of parameters
  • PK/PD modeling