In Vitro Metabolism
Determine drug metabolism using enzyme-mediated reactions. Metabolism plays an important role in drug efficacy and safety. Drug metabolite(s) can be identified from biological samples (e.g., plasma, urine) using LC-MS/MS. The species/strains/organ/individual-specific metabolic profiles, metabolic drug-drug interactions, metabolic kinetics can also be determined using microsome/S9 fraction/recombinant enzymes-mediated reactions.