Computer (PHATMCDCLAB07)
Software:
WinNonLin / Phoenix from Certara
Phoenix NLME from Certara
GastroPlus from Simulation Plus
SigmaPlot
Graphpad Prism
SAS
Application:
Consultation on Experimental Design for PK/PD Correlation and Modeling Analyses
PK Modeling Development and Simulation
- Individual PK Modeling
- Pop PK Modeling
- Advanced Modelings
- Parent/metabolite Co-modeling
- Enterohepatic cycling modeling
- PBPK modeling (with Biodistribution profiles)
PD Modeling and Determination of Parameters (Emax and EC50)
- Emax model
- Sigmoidal Emax model
PK/PD Modeling
- Direct effect model
- Indirect effect model
- Define predictive pk parameter(s) for pd outcomes
- Define exposure/efficacy and exposure/toxicity levels
- Guide dosing strategy by recommending rational dose and dose regimen for further efficacy studies
- Interspecies allometric scaling to project pk parameters in humans, and recommend first in human (fih) dose for ind application